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HIGHLIGHT
- The study, covering 80 % of Italian population, analyzes data from 34 Cancer Registries of the AIRTUM network for the period 2013–2017 (1359053 cases)
- Incidence rates (ASR): men 657.1/100,000, women 475.5/100,000. Mortality rates (ASMR): men 331.8/100,000, women 188.8/100,000
- The cumulative risk of developing cancer is 1 in 2 men and 1 in 3 women
- Most frequent cancers: Men: Prostate (18 %), Lung (15 %), Colorectal (13 %). Women: Breast (31 %), Colorectal (12 %), Lung (7 %)
- Geographic Differences in incidence and mortality were present and their ranking depended on cancer site
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Abstract
As national cancer survival estimates in Italy date back to 2011, we provided updated figures using population-based cancer registries. Analyses by age and sex included 1.418.044 cancers diagnosed between 2013 and 2017 from 34 registries covering 48 million residents. The 2008–2017 period, with 20 registries covering 24 million residents, was used for trends and regional comparisons. Net survival was estimated by Pohar-Perme method with life tables by year, sex, residence and calculated using the international standard distribution. Five-year age-standardized net survival for all cancers combined was 66.7 % in females and 62.2 % in males. Females had better survival than males for most cancers, notably acute lymphatic leukaemia (+9 % points (pp)), upper respiratory/digestive (+9 pp), lung (+6 pp), CNS (+5 pp), and stomach (+4 pp). Males had a higher survival for bladder (+4 pp), kidney (+2 pp), and urinary cancers (+5 pp). Best outcomes (>75 %) were documented for prostate, testicular, breast, endometrial, thyroid, melanoma, Hodgkin lymphoma, bladder, and chronic lymphatic leukaemia. Poorest prognosis ( 40 % points gaps in some haematological cancers. From 2008–2017, net survival arose from 65.7 % to 70.7 % in men and from 69.9 % to 74.1 % in women. Improvements were seen for pancreas, lung, and acute leukaemias, mainly in women, while decreases affected bladder, cervical, chronic lymphatic leukaemia in men. Geographical disparities persisted, with higher survival in Northern-Central Italy (64.0 % for men and 68.3 % for women) than in Southern-Islands (58.1 % for men and 63.7 %, for women). Our findings confirmed a better prognosis for younger patients and females than male patients. Survival has continued to improve over time, even at a higher improving rate in the considered period than the past.